Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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China pillow ODM development service
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China pillow OEM manufacturer
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand graphene material ODM solution
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Arch support insole OEM from Vietnam
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan custom product OEM/ODM manufacturing factory
Harvard Medical School researchers have discovered that Staphylococcus aureus directly causes itch by activating nerve cells. This finding, based on mouse and human cell studies, challenges the traditional view that itch in skin conditions arises from inflammation. It opens new possibilities for treating chronic itch and understanding its evolutionary significance. Researchers discover that a common microbe is an unrecognized cause of itching. Researchers at Harvard Medical School have discovered that the bacterium Staphylococcus aureus, commonly found on the skin, can directly trigger itching by interacting with nerve cells. The findings, based on research in mice and in human cells, was recently published in the journal Cell. This study provides a significant insight into the longstanding mystery of itching and sheds light on why skin disorders such as eczema and atopic dermatitis are often accompanied by persistent itch. In such conditions, the equilibrium of microorganisms that keep our skin healthy is often thrown off balance, allowing S. aureus to flourish, the researchers said. Up until now, the itch that occurs with eczema and atopic dermatitis was believed to arise from the accompanying inflammation of the skin. But the new findings show that S. aureus single-handedly causes itch by instigating a molecular chain reaction that culminates in the urge to scratch. “We’ve identified an entirely novel mechanism behind itch — the bacterium Staph aureus, which is found on almost every patient with the chronic condition atopic dermatitis. We show that itch can be caused by the microbe itself,” said senior author Isaac Chiu, associate professor of immunology in the Blavatnik Institute at HMS. The study experiments showed that S. aureus releases a chemical that activates a protein on the nerve fibers that transmit signals from the skin to the brain. Treating animals with an FDA-approved anti-clotting medicine successfully blocked the activation of the protein to interrupt this key step in the itch-scratch cycle. The treatment relieved symptoms and minimized skin damage. Credit: Harvard Medical School The findings can inform the design of oral medicines and topical creams to treat persistent itch that occurs with various conditions linked to an imbalance in the skin microbiome, such as atopic dermatitis, prurigo nodularis, and psoriasis. The repeated scratching that is a hallmark of these conditions can cause skin damage and amplify inflammation. “Itch can be quite debilitating in patients who suffer from chronic skin conditions. Many of these patients carry on their skin the very microbe we’ve now shown for the first time can induce itch,” said study first author Liwen Deng, a postdoctoral research fellow in the Chiu Lab. Identifying the molecular spark plug that ignites itch Researchers exposed the skin of mice to S. aureus. The animals developed an intensifying itch over several days, and the repeated scratching caused worsening skin damage that spread beyond the original site of exposure. Moreover, mice exposed to S. aureus became hypersensitive to innocuous stimuli that would not typically cause itch. The exposed mice were more likely than unexposed mice to develop abnormal itching in response to a light touch. This hyperactive response, a condition called alloknesis, is common in patients with chronic conditions of the skin characterized by persistent itch. But it can also happen in people without any underlying conditions — think of that scratchy feeling you might get from a wool sweater. To determine how the bacterium triggered itch, the researchers tested multiple modified versions of the S. aureus microbe that were engineered to lack specific pieces of the bug’s molecular makeup. The team focused on 10 enzymes known to be released by this microbe upon skin contact. One after another, the researchers eliminated nine suspects — showing that a bacterial enzyme called protease V8 was single-handedly responsible for initiating itch in mice. Human skin samples from patients with atopic dermatitis also had more S. aureus and higher V8 levels than healthy skin samples. The analyses showed that V8 triggers itch by activating a protein called PAR1, which is found on skin neurons that originate in the spinal cord and carry various signals —touch, heat, pain, itch — from the skin to the brain. Normally, PAR1 lies dormant but upon contact with certain enzymes, including V8, it gets activated. The research showed that V8 snips one end of the PAR1 protein and awakens it. Experiments in mice showed that once activated, PAR1 initiates a signal that the brain eventually perceives as an itch. When researchers repeated the experiments in lab dishes containing human neurons, they also responded to V8. Interestingly, various immune cells implicated in skin allergies and classically known to cause itch — mast cells and basophils — did not drive itch after bacterial exposure, the experiments showed. Nor did inflammatory chemicals called interleukins, or white cells, which are activated during allergic reactions and are also known to be elevated in skin diseases and even in certain neurologic disorders. “When we started the study, it was unclear whether the itch was a result of inflammation or not,” Deng said. “We show that these things can be decoupled, that you don’t necessarily have to have inflammation for the microbe to cause itch, but that the itch exacerbates inflammation on the skin.” Interrupting the itch-scratch cycle Because PAR1 — the protein activated by S. aureus — is involved in blood clotting, researchers wanted to see whether an already approved anticlotting drug that blocks PAR1 would stop itch. It did. The itchy mice whose skin was exposed to S. aureus experienced rapid improvement when treated with the drug. Their desire to scratch diminished dramatically, as did the skin damage caused by scratching. Moreover, once treated with PAR1 blockers, the mice no longer experienced abnormal itch in response to innocuous stimuli. The PAR1 blocker is already used in humans to prevent blood clots and could be repurposed as anti-itch medication. For example, the researchers noted, the active ingredient in the medicine could become the basis for anti-itch topical creams. One immediate question that the researchers plan to explore in future work is whether other microbes besides S. aureus can trigger itch. “We know that many microbes, including fungi, viruses, and bacteria, are accompanied by itch but how they cause itch is not clear,” Chiu said. Beyond that, the findings raise a broader question: Why would a microbe cause itch? Evolutionarily speaking, what’s in it for the bacterium? One possibility, the researchers said, is that pathogens may hijack itch and other neural reflexes to their advantage. For example, previous research has shown that the TB bacterium directly activates vagal neurons to cause cough, which might enable it to spread more easily from one host to another. “It’s a speculation at this point, but the itch-scratch cycle could benefit the microbes and enable their spread to distant body sites and to uninfected hosts,” Deng said. “Why do we itch and scratch? Does it help us, or does it help the microbe? That’s something that we could follow up on in the future.” Reference: “S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis” by Liwen Deng, Flavia Costa, Kimbria J. Blake, Samantha Choi, Arundhasa Chandrabalan, Muhammad Saad Yousuf, Stephanie Shiers, Daniel Dubreuil, Daniela Vega-Mendoza, Corinne Rolland, Celine Deraison, Tiphaine Voisin, Michelle D. Bagood, Lucia Wesemann, Abigail M Frey, Joseph S. Palumbo, Brian J. Wainger, Richard L. Gallo, Juan-Manuel Leyva-Castillo, Nathalie Vergnolle, Theodore J. Price, Rithwik Ramachandran, Alexander R. Horswill and Isaac M. Chiu, 22 November 2023, Cell. DOI: 10.1016/j.cell.2023.10.019 The work was funded by the National Institutes of Health (grants R01AI168005, R01AI153185, R01NS065926, R01NS102161, R01NS111929, R37AI052453, R01AR076082, U01AI152038, UM1AI151958, R01AI153185, R01JL160582, F32AI172080, T32AI049928, 1R21AG075419), Food Allergy Science Initiative (FASI), Burroughs Wellcome Fund, Drako Family Fund, Jackson-Wijaya Research Fund, Canadian Institutes of Health Research (CIHR) (grants 376560 and 469411), and ANR-PARCURE (PRCE-CE18, 2020). Chiu serves on the scientific advisory board of GSK Pharmaceuticals. Provisional patent application Serial No. 63/438,668, in which some coauthors are listed as inventors, was filed based on these findings.
This study identified key structural components of the sodium ion pathways in the stator of the bacterial flagellar motor. It also uncovered some of the structural changes that the stator undergoes as ions flow through it, and how specific mutations and chemicals can interfere with this function. Credit: Tatsuro Nishikino from Nagoya Institute of Technology Electron microscopy images reveal crucial structures and mechanisms within the molecular machinery that certain bacteria use for propulsion. When discussing motors, most people think of those in vehicles or machines. However, biological motors have existed for millions of years in microorganisms. Many bacteria use tail-like structures called flagella, which rotate to propel them through fluids. This movement is driven by a protein complex known as the flagellar motor. The flagellar motor has two key components: the rotor and the stators. The rotor, a large rotating structure anchored to the cell membrane, drives flagellum movement. The stators, smaller structures surrounding the rotor, contain ion pathways that transport protons or sodium ions, depending on the bacterial species. As these charged particles pass through, the stators undergo structural changes that exert force on the rotor, causing it to spin. While extensive research has focused on the stators, the exact structure and function of their ion pathways remain unclear. A Closer Look at the Flagellar Motor in Vibrio alginolyticus Against this backdrop, a research team led by Assistant Professor Tatsuro Nishikino from Nagoya Institute of Technology analyzed the flagellar motor in the bacterial species Vibrio alginolyticus. Other members of the team included Norihiro Takekawa and Katsumi Imada from Osaka University, Jun-ichi Kishikawa from Kyoto Institute of Technology, and Seiji Kojima from Nagoya University. Their findings were published in Proceedings of the National Academy of Sciences of the United States of America on December 30, 2024. This video presents a study in which, using cryo-electron microscopy, researchers determined the structure and mechanisms of a key component in the flagellar motor, which bacteria use to turn their flagella and move. Credit: Tatsuro Nishikino from Nagoya Institute of Technology The researchers employed cryo-electron microscopy (CryoEM), a powerful technique that captures high-resolution images of biomolecules by rapidly freezing them and imaging them with an electron microscope. Using CryoEM on normal and genetically modified V. alginolyticus, the team took snapshots of stator complexes in different states and identified key molecular cavities for sodium ions. Based on the results, the team proposed a model describing how sodium ions flow through the stator. Briefly put, the subunits that form the stators in Vibrio alginolyticus, arranged in a ring, act as size-based filters that allow the intake of sodium ions—but not other ions—into the identified cavities. The researchers also determined the mechanisms by which phenamil, an ion-channel blocker, inhibits the flow of sodium ions through the stator. Proposed Model of Sodium Ion Flow The findings of this study could have important medical implications. “Flagellar-based movement is involved in infections and toxicity of some species of pathogenic bacteria. One motivation behind this study was finding ways of inactivating such bacteria by restricting their movement. Thus, understanding the molecular mechanism of flagellar motility will be key for achieving this,” remarks Tatsuro. Moreover, knowledge of flagellar motors could lead to innovative designs for microscopic machines. “Flagellar motors are molecular nanomachines with a diameter of roughly 45 nm and an energy conversion efficiency of approximately 100%. Our findings are a big step to clarify their torque-generation mechanisms, which would be essential for the engineering of nanoscale molecular motors,” concludes Tatsuro. Let us hope further studies clarify all the details of these amazing natural machines! Reference: “Structural insight into sodium ion pathway in the bacterial flagellar stator from marine Vibrio” by Tatsuro Nishikino, Norihiro Takekawa, Jun-ichi Kishikawa, Mika Hirose, Seiji Kojima, Michio Homma, Takayuki Kato and Katsumi Imada, 30 December 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2415713122
Researchers have discovered that an RNA molecule, not a protein, controls black pigment patterns on butterfly wings, challenging previous genetic assumptions and revealing new insights into trait evolution. New research uncovers a surprising genetic mechanism that impacts the development of butterfly wing colors An international team of researchers has revealed an unexpected genetic process that shapes the intricate and colorful patterns on butterfly wings. Published in the Proceedings of the National Academy of Sciences, the study led by Luca Livraghi from George Washington University and the University of Cambridge, identifies an RNA molecule, rather than a protein as previously believed, as crucial in controlling the spread of black pigment on butterfly wings. Precisely how butterflies are able to generate the vibrant patterns and colors on their wings has fascinated biologists for centuries. The genetic code contained within the cells of developing butterfly wings dictates the specific arrangement of the color on the wing’s scales—the microscopic tiles that form wing patterns—similar to the arrangement of colored pixels to form a digital image. Cracking this code is fundamental to understanding how our own genes build our anatomy. In the lab, researchers can manipulate that code in butterflies with gene-editing tools and observe the effect on visible traits, such as coloration on a wing. The Role of Protein-Coding Genes Scientists have long known that protein-coding genes are crucial to these processes. These types of genes create proteins that can dictate when and where a specific scale should generate a particular pigment. When it comes to black pigments, researchers thought this process would be no different, and initially implicated a protein-coding gene. The new research, however, paints a different picture. Shown here is a painted lady butterfly with genetically altered wing patterns. Thedark pigmentation was lost in one set of wings after gene editing with CRISPR, which disabled acrucial RNA molecule responsible for regulating wing color. Credit: Luca Livraghi The team discovered a gene that produces an RNA molecule—not a protein—controls where dark pigments are made during butterfly metamorphosis. Using the genome-editing technique CRISPR, the researchers demonstrated that when you remove the gene that produces the RNA molecule, butterflies completely lose their black pigmented scales, showing a clear link between RNA activity and dark pigment development. RNA as an Evolutionary Paintbrush “What we found was astonishing,” said Livraghi, a postdoctoral scientist at GW. “This RNA molecule directly influences where the black pigment appears on the wings, shaping the butterfly’s color patterns in a way we hadn’t anticipated.” The researchers further explored how the RNA molecule functions during wing development. By examining its activity, they observed a perfect correlation between where the RNA is expressed and where black scales form. “We were amazed that this gene is turned on where the black scales will eventually develop on the wing, with exquisite precision,” said Arnaud Martin, associate professor of biology at GW. “It is truly an evolutionary paintbrush in this sense, and a creative one, judging by its effects in several species.” Depicted is a longwing butterfly resting on a Lantana flower. Its wing patterns have been modified through CRISPR gene editing, which removed a crucial RNA molecule, leading to a loss of melanic scales. Credit: Luca Livraghi, a postdoctoral scientist at GW The researchers examined the newly discovered RNA in several other butterflies whose evolutionary history diverged around 80 million years ago. They found that in each of these species, the RNA had evolved to control new placements in the patterns of dark pigments. “The consistent result obtained from CRISPR mutants in several species really demonstrate that this RNA gene is not a recent invention, but a key ancestral mechanism to control wing pattern diversity,” said Riccardo Papa, professor of biology at the University of Puerto Rico – Río Piedras. “We and others have now looked at this genetic trait in many different butterfly species, and remarkably we are finding that this same RNA is used again and again, from longwing butterflies, to monarchs and painted lady butterflies,” said Joe Hanly, a postdoctoral scientist and visiting fellow at GW. “It’s clearly a crucial gene for the evolution of wing patterns. I wonder what other, similar phenomena biologists might have been missing because they weren’t paying attention to the dark matter of the genome.” The findings not only challenge long-standing assumptions about genetic regulation but also open up new avenues for studying how visible traits evolve in animals. Reference: “A long noncoding RNA at the cortex locus controls adaptive coloration in butterflies” by Luca Livraghi, Joseph J. Hanly, Elizabeth Evans, Charlotte J. Wright, Ling S. Loh, Anyi Mazo-Vargas, Kiana Kamrava, Alexander Carter, Eva S. M. van der Heijden, Robert D. Reed, Riccardo Papa, Chris D. Jiggins and Arnaud Martin, 30 August 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2403326121 The research was supported by the National Science Foundation and the Biotechnology and Biological Sciences Research Council.
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